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Acyclic analogues of purine nucleosides with dimethylaminoethyl and dimethylaminoethoxyalkyl side chains: preparation, one- and two-dimensional 1H- and 13C-NMR studies

The novel acyclic analogues of purine nucleosides containing 6-N-[2-(dimethylamino)ethyl] and 9-(2-hydroxyalkyl) substituents (6, 7), or 9-[2-(2-(dimethylamino)ethoxy)alkyl] substituent and 6-amino group free (5) or transformed into pyrrolo moiety (11, 12), were prepared by reaction of protected 9-(2-hydroxyalkyl)adenines with 2-(dimethylamino)ethyl chloride hydrochloride. The substitution site in the purine ring was determined by 1H and 13C NMR, using chemical and substituent induced shifts, H-H and C-H coupling constants and connectivities in twodimensional homo- and heteronuclear correlation spectra.

acyclonucleosides ; purine ; adenine ; 1H NMR ; 13C NMR ; 2D homo- and heteronuclear correlation spectra

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