Microbiological decontamination of botanical raw materials and corresponding pharmaceutical products by irradiation (CROSBI ID 93591)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Katušin-Ražem, Branka ; Novak, Boris ; Ražem, Dušan
engleski
Microbiological decontamination of botanical raw materials and corresponding pharmaceutical products by irradiation
Microbial contamination typical of botanical raw materials used in the manufacture of pharmaceuticals decreases with the increasing level of processing, on going from flowers and leaves 104 - 108 CFU/g), to fruits and seeds (102 - 106 CFU/g), to liquid extracts (104 106 CFU/g), and to dry extracts (102 105 CFU/g). At the same time the resistivity of microflora to irradiation, expressed as a dose required for the first 90 % reduction, increases along the same assortment as 2, 4, 5 and 5 kGy, respectively. This results in doses between 4 and 30 kGy required to treat typical contamination, or between 10 and 40 kGy for a severe case. The contamination of final products, phyto-therapeutic ointments (104 107 CFU/g), is relatively sensitive to irradiation (Dfirst 90 % red = 1 kGy) and usually does not require doses higher than 8 kGy.
Microbiological contamination; botanical raw materials; irradiation dectontamination; herbs; radiosensitivity
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano