engleski

Prediction of protein functional domains from sequences using artificial neural networks.

An artificial neural network (ANN) solution is described for the recognition of domains in protein sequences. A query sequence is first compared to a reference database of domain sequences using BLAST and the output data, encoded in the form of 6 parameters, are forwarded to feed-forward artificial neural networks with 6 input and 6 hidden units with sigmoidal transfer function. The recognition is based on the distribution of BLAST scores precomputed for the known domain groups in a database vs. database comparison. Applications to the prediction of function are discussed.

BLAST; Artificial neural network; Protein sequences

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