engleski

Effect of Earthworm extract (G-90) on formation and lysis of clots originated from venous blood of dogs with cardiopathies and with malignant tumors

The stability of homeostasis is important to keep a balance between coagulation and fibrinolysis. A disorder of homeostasis leads to the different physiological changes and causes the different disease such as cardiopathies and malignant tumors. The cardiopathies is characterized by a hypercoagulation. Un the malignant tumors, besides the hypercoagulation due to plasminogen activators (PA) formed inside the tumor, a disorder of homeostasis leads also to acceleration of the fibrinolysis. The variety of internal and external factors in both cases determine the deviation of time for the clots formation, as well as the lyses of blood and fibrin clots. In this study the venous blood as well as the blood and the fibrin clots, derived from healthy dogs, the dogs with cardiopathies and with malignant tumors, were examined for the time of coagulation and fibronolysis by adding a different substances. In these experiments we used a glycolipoprotein extract from earthworm tissue homogenate (G-90) and the proteolytic enzymes P I and P II, isolated from G-90. The efficacy of tested substances was comparable with the clinically administered anticoagulants. The most significant differences in clotting time among the three tested groups of dogs were obtained by application of the original G-90, along with the fibrinolytic enzymes and other biologically active factors, also contains a factor that decelerates the formation of clotin a specific medium, such as the blood from the dogs with malignant tumors.

homeostasis; cardiopathy; malignant tumors; earthworm extract (G90)

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