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Preparation of Nanosized Drug Particles by the Coating of Inorganic Particles: Naproxen and Ketoprofen on Alumina

Nanosized alumina particles with modal diameters of 8 and 13 nm, respectively, were successfully coated by adsorption of naproxen [(+)-6-methoxy-alfa-methyl-2-naphthalene-acetic acid] and ketoprofen [alfa-methyl-3-(4-methylbenzoil) benzene acetic acid] in aqueous and ethanol solutions. The presence of the drugs at alumina sur-face was confirmed by attenuated total reflection infrared spectroscopy and electrokinetic measurements, while their bound amounts were assessed by thermogravimetric analysis.

adsorption of drugs; alumina; nanoparticles; drugs; ketoprofen; naproxene

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