A spin labelling study of the hydrophobic barrier in liposomes (CROSBI ID 483732)
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Podaci o odgovornosti
Noethig-Laslo, Vesna ; Cevc, Pavle ; Arcon, Denis ; Šetjurc, Marjeta
engleski
A spin labelling study of the hydrophobic barrier in liposomes
A fundamental property of biological membrane is to act as a barrier to permeation of polar molecules. This barrier effect is largely due to a hydrophobicity of a phospholipid bilayer, determined by the extent of water penetration into the membrane. In order to study the depth of water penetration into liposomes, we used the electron spin echo modulation, a pulsed electron spin resonance method(1)that takes advantage of the solvent effect on the hyperfine interaction of the nitroxide spin labels. A fatty acids with the paramagnetic nitroxide group of the spin label covalently attached at a various positions along the fatty acid chain was introduced into the multilamellar liposomes. The hydrophobic barrier for water molecules, as well as, for small molecules such as a glycine, was studied as a function of the liposome composition and size.
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Podaci o prilogu
53.-x.
2002.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
First Workshop of the COST Chemistry Action D 27 on Prebiotic Chemistry and Early Evolution
poster
01.01.2002-01.01.2002
Ravello, Italija