engleski

The effect of opioid agonists of delta-class DSLET, mu-class DAMGO, kappa-class U-69593 and an opioid antagonist, naloxone, on MTT activity of NALM-1 leukemic cells.

The effects of synthetic agonists of delta-, mu-, kappa-opioid classes were studied on proliferation of NALM-1 leukemic cells, using MTT-test. delta-opioid DSLET and mu-opioid DAMGO mildly and transiently decreased MTT-activity of NALM-1 cells after 6 hours treatment.The kappa-opioid agonist U-69593 mildly suppressed proliferation of NALM-1 cells after 48 hours treatment. Naloxone, an opioid receptor antagonist, mildly and transiently diminished MTT-activity of NALM-1 cells after 6 hours treatment. DAMGO, DSLET, U-69593, and an opioid antagonist naloxone did not trigger DNA fragmentation.

opioid agonists; NALM-1 leukemic cells; MTT-test

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