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izvor podataka: crosbi

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans (CROSBI ID 265118)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Russell, Alyce C. ; Kepka, Agnieszka ; Trbojević-Akmačić, Irena ; Ugrina, Ivo ; Song, Manshu ; Hui, Jennie ; Hunter, Michael ; Laws, Simon M. ; Lauc, Gordan ; Wang, Wei Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans // Immunobiology, 224 (2019), 1; 110-115. doi: 10.1016/j.imbio.2018.10.002

Podaci o odgovornosti

Russell, Alyce C. ; Kepka, Agnieszka ; Trbojević-Akmačić, Irena ; Ugrina, Ivo ; Song, Manshu ; Hui, Jennie ; Hunter, Michael ; Laws, Simon M. ; Lauc, Gordan ; Wang, Wei

engleski

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans

Background Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fragment crystallisable portion is involved in mediating this process. Body mass index, a rudimentary yet gold standard indication for body fat, has been shown to be associated with agalactosylated immunoglobulin G N-glycans. Aim We aimed to determine the association between increased body fat and the immunoglobulin G glycosylation features, comparing body mass index to other measures of body fat distribution. Methods We investigated a sample of 637 community-based 45–69 year olds, with mixed phenotypes, residing in Busselton, Western Australia. Body mass index and the waist-to-hip and waist-to-height ratios were calculated using anthropometry, while dual- energy x-ray absorptiometry was performed to gain an accurate measure of total and area specific body fat. Serum immunoglobulin GN- glycans were analysed by ultra-performance liquid chromatography. Results Twenty-two N- glycan peaks were found to be associated with at least one of the fat measures. While the previous association of body mass index to agalactosylated immunoglobulin G was replicated, measures of central adiposity explained the most variation in the immunoglobulin G glycome. Conclusion Central adiposity is associated with an increased pro- inflammatory fraction of immunoglobulin G, suggesting that the android/gynoid ratio or waist-to-height ratio instead be considered when controlling for adiposity in immunoglobulin G glycome biomarker studies.

Body mass index ; Central adiposity ; Glycosylation ; Immunoglobulin G ; Pro-inflammation

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Podaci o izdanju

224 (1)

2019.

110-115

objavljeno

0171-2985

10.1016/j.imbio.2018.10.002

Povezanost rada

Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti

Poveznice
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