engleski

Comparative study of polyphenolic composition and anti-inflammatory activity of Thymus species

The polyphenolic composition and anti-infammatory activity of selected Thymus species (T. longicaulis C. Presl, T. praecox Opiz subsp. polytrichus (A. Kerner Ex Borbás) Jalas, T. pulegioides L., T. serpyllum L. subsp. serpyllum and T. striatus Vahl) was studied in comparison with T. vulgaris, as an ofcinal medicinal plant, to evaluate the biomedical potential of these Croatian wild-growing species. This paper provides a frst insight into the polyphenolic profles of T. praecox subsp. polytrichus and T. striatus. Also, some favone and hydroxycinnamic derivatives were at frst identifed in the other studied species by LC-DAD-ESI–MS/MS analysis. Rosmarinic acid and glycosides of scutellarein and luteolin were found to be the most abundant polyphenolic constituents. The Thymus extracts inhibited Src tyrosine kinase activity and they reduced the production of proinfammatory cytokine interleukin-6 in Balb/C mice splenocytes. The obtained results highlighted T. longicaulis as a potential source of herbal drugs with anti-infammatory properties and/or novel functional food rich in favonoids and phenolic acids.

Thymus spp. ; Rosmarinic acid ; Luteolin ; Scutellarein ; Src tyrosine kinase ; Interleukin-6

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