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IgG glycans as a biomarker of biological age

Immunoglobulin G (IgG) has an important role in various processes of the immune response and its functions can be modulated by N-glycans attached to its Fab and Fc portions. The composition of IgG glycans can be deciphered using different analytical methods, based on liquid chromatography, mass spectrometry and capillary electrophoresis. IgG glycome composition is partly heritable, but is also under the influence of various environmental factors. It therefore represents an interface between genes and environment, as evidenced by IgG glycosylation pattern changes associated with chronological age, various diseases and lifestylerelated variables. IgG glycans are therefore considered an excellent biomarker of the general health state of a person, i.e. biological age.

IgG glycome ; aging ; diseases ; biological age ; biomarker ; inflammaging

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