Heritability of Human Plasma N-Glycome (CROSBI ID 271885)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Zaytseva, Olga O. ; Freidin, Maxim B. ; Keser, Toma ; Štambuk, Jerko ; Ugrina, Ivo ; Šimurina, Mirna ; Vilaj, Marija ; Štambuk, Tamara ; Trbojević-Akmačić, Irena ; Pučić-Baković, Maja ; Lauc, Gordan ; Williams, Frances M. K. ; Novokmet, Mislav
engleski
Heritability of Human Plasma N-Glycome
The N-glycosylation profile of total human plasma proteins could be a useful biomarker for various pathological states. Reliable high- throughput methods for such profiling have been developed. However, studies of relative importance of genetic and environmental factors in regulating plasma N-glycome are scarce. The aim of our study was to determine the role of genetic factors in phenotypic variation of plasma N-glycan profile through the estimates of its heritability. Thirty-nine total plasma N-glycome traits were analyzed in 2816 individuals from the TwinsUK data set. For the majority of the traits, high heritability estimates (>50%) were obtained pointing at a significant contribution of genetic factors in plasma N-glycome variation, especially for glycans mostly attached to immunoglobulins. We have also found several structures with higher environmental contribution to their variation.
N-glycosylation ; heritability of glycosylation ; human plasma glycome ; glycan analysis
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Podaci o izdanju
19 (1)
2020.
85-91
objavljeno
1535-3893
1535-3907
10.1021/acs.jproteome.9b00348
Povezanost rada
Farmacija, Interdisciplinarne prirodne znanosti