Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases (CROSBI ID 274949)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Martin, Tiphaine C. ; Šimurina, Mirna ; Ząbczyńska, Marta ; Martinić Kavur, Marina ; Rydlewska, Magdalena ; Pezer, Marija ; Kozłowska, Kamila ; Burri, Andrea ; Vilaj, Marija ; Turek-Jabrocka, Renata ; Krnjajić-Tadijanović, Milena ; Trofimiuk-Müldner, Małgorzata ; Ugrina, Ivo ; Lityńska, Anna ; Hubalewska-Dydejczyk, Alicja ; Trbojević-Akmačić, Irena ; Lin, Ee Mun ; Walsh, John P. ; Pocheć, Ewa ; Spector, Tim D. ; Wilson, Scott G. ; Lauc, Gordan
engleski
Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases
Autoimmune thyroid diseases (AITD) are the most common group of autoimmune diseases, associated with lymphocyte infiltration and the production of thyroid autoantibodies, like thyroid peroxidase antibodies (TPOAb), in the thyroid gland. Immunoglobulins and cell-surface receptors are glycoproteins with distinctive glycosylation patterns that play a structural role in maintaining and modulating their functions. We investigated associations of total circulating IgG and peripheral blood mononuclear cells glycosylation with AITD and the influence of genetic background in a case- control study with several independent cohorts and over 3, 000 individuals in total. The study revealed an inverse association of IgG core fucosylation with TPOAb and AITD, as well as decreased peripheral blood mononuclear cells antennary α1, 2 fucosylation in AITD, but no shared genetic variance between AITD and glycosylation. These data suggest that the decreased level of IgG core fucosylation is a risk factor for AITD that promotes antibody- dependent cell-mediated cytotoxicity previously associated with TPOAb levels.
antibodies ; antibody-dependent cell-mediated cytotoxicity (ADCC) ; autoimmune thyroid disease ; fucosylation ; glycoproteins ; glycosylation ; igg ; immunology ; patient cohorts ; thyroid peroxidase antibodies (TPOAB)
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Podaci o izdanju
19 (5)
2020.
774-792
objavljeno
1535-9476
1535-9484
10.1074/mcp.ra119.001860
Povezanost rada
Biologija, Kliničke medicinske znanosti, Temeljne medicinske znanosti