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What have we learned about antinociceptive effect of botulinum toxin type A from mirror-image pain models? (CROSBI ID 297047)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Drinovac Vlah, Višnja ; Bach-Rojecky, Lidija What have we learned about antinociceptive effect of botulinum toxin type A from mirror-image pain models? // Toxicon, 185 (2020), 164-173. doi: 10.1016/j.toxicon.2020.07.014

Podaci o odgovornosti

Drinovac Vlah, Višnja ; Bach-Rojecky, Lidija

engleski

What have we learned about antinociceptive effect of botulinum toxin type A from mirror-image pain models?

Mirror pain represents pain with complex pathophysiological background experienced at both sides of the body, usually after unilateral injury. Although observed almost 10 years ago, the phenomenon of bilateral antinociceptive effect of botulinum toxin type A (BoNT/A) following its unilateral administration in experimental mirror- image pain (MP) models remains challenging and intriguing task to explain. Data generated so far using MP models and mechanisms behind this unique feature of BoNT/A might influence the overall understanding of its mechanism of antinociceptive action. Here we review the effects contributing to BoNT/A's bilateral antinociceptive action observed in experimental MP models.

bilateral antinociceptive effect ; botulinum neurotoxin type A ; mirror pain ; synaptosomal-associated protein of 25 kDa

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Podaci o izdanju

185

2020.

164-173

objavljeno

0041-0101

10.1016/j.toxicon.2020.07.014

Povezanost rada

Farmacija, Temeljne medicinske znanosti

Poveznice
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