engleski

A new synthetic route for the preparation of glycoprobes

Glycoprobes are a novel tool that we have recently developed to simplify analysis of lectin activity in complex biological samples. Although proven effective, their shortcoming was the relatively complex procedure for the incorporation of ligands and very low water-solubility of pre-glycoprobe that did not allow incorporation of charged ligands like e.g. sialylated carbohydrates. Here we describe a new approach for the synthesis of glycoprobes that enables simpler synthesis of functional glycoprobes and at the same time enables incorporation of water-soluble ligands.

Glycoprobes; Neoglycoconjugates; Digoxin; Lectins; Method

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