Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids (CROSBI ID 107063)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Barbarić, Monika ; Uršić, Stanko ; Pilepić, Viktor ; Zorc, Branka ; Hergold-Brundić, Antonija ; Nagl, Ante ; Grdiša, Mira ; Pavelić, Krešimir ; Snoeck, Robert ; Andrei, Graciela et al. Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids // Journal of medicinal chemistry, 48 (2005), 884-887. doi: 10.1021/jm040878r

Podaci o odgovornosti

Barbarić, Monika ; Uršić, Stanko ; Pilepić, Viktor ; Zorc, Branka ; Hergold-Brundić, Antonija ; Nagl, Ante ; Grdiša, Mira ; Pavelić, Krešimir ; Snoeck, Robert ; Andrei, Graciela ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen

engleski

Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluation of the Novel Cycloalkyl-N-aryl-hydroxamic Acids

In vitro evaluation of the novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a-g) demonstrates that the compounds 2b, d, e and g exhibited rather marked inhibitory activity (IC50 = 7-10 uM) against malignant tumor cell lines: colon carcinoma (SW620), laryngeal carcinoma (Hep2), pancreatic carcinoma (MiaPaCa2). Compound 2e showed the most pronounced anti-CMV activity (EC50 = 1.5 and 0.8 ug mL-1) only at ≥ 5-fold lower than the cytotoxic concentration. Compounds 2d and 2f showed modest, albeit selective activity against cytomegalovirus (2d: EC50 = 7.3-8.9 ug mL-1, selectivity index 7-10, and 2f: EC50 = 7-13 ug mL-1 and selectivity index 10).

hydroxamic acids ; cytostatic evaluation ; antiviral evaluation ; crystalography

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

48

2005.

884-887

objavljeno

0022-2623

1520-4804

10.1021/jm040878r

Povezanost rada

Kemija

Poveznice
Indeksiranost