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Positive regulation of ERK activation and MKP-1 expression by peroxovanadium complex bpV (phen) (CROSBI ID 112269)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Rumora, Lada ; Hadžija, Mirko ; Maysinger, Dusica ; Žanić-Grubišić, Tihana Positive regulation of ERK activation and MKP-1 expression by peroxovanadium complex bpV (phen) // Cell biology and toxicology, 20 (2004), 293-301. doi: 10.1007/s10565-004-5104-5

Podaci o odgovornosti

Rumora, Lada ; Hadžija, Mirko ; Maysinger, Dusica ; Žanić-Grubišić, Tihana

engleski

Positive regulation of ERK activation and MKP-1 expression by peroxovanadium complex bpV (phen)

Lower micromolar concentrations of peroxovanadium compound potassium bisperoxo(1, 10-phenanthroline)oxovanadate (V)  bpV (phen) stimulate RINm5F cell metabolic activity. 1 and 3  M bpV (phen) induces strong and sustained activation of extracellular signal-regulated kinase (ERK). However, it seems that bpV (phen) does not effect c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) phosphorylation. In addition, bpV (phen) induces mitogen-activated protein kinase phosphatase-1 (MKP-1) expression. We found that ERK activation could be completely abolished if RINm5F cells were incubated with both bpV (phen) and PD 98059, a specific inhibitor of upstream ERK kinase MEK1. On the other hand, this combined treatment up-regulated activation of stress kinases, JNK and p38 MAPK, significantly suppressed MKP-1 expression and induced cell death. Thus, our results suggest that the mechanism underlying bpV (phen) survival-enhancing effect could be associated with induced ERK activation and MKP-1 expression.

apoptosis ; mitogen-activated protein kinase ; mitogen-activated protein kinase phosphatase-1 ; peroxovanadium

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Podaci o izdanju

20

2004.

293-301

objavljeno

0742-2091

10.1007/s10565-004-5104-5

Povezanost rada

Temeljne medicinske znanosti, Farmacija

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