Synthesis of sulfamethoxazole metabolites (CROSBI ID 468384)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Lovrek, Monika ; Zorc, Branka ; Butula, Ivan
engleski
Synthesis of sulfamethoxazole metabolites
Sulfamethoxazole (SMX) is a well known antibacterial drug. Most serious side effects of sulfamethoxazole and other sulfonamides are hypersensitivity reactions, the pathogenesis of which has been suggested to be mediated by reactive metabolites. We report here the new synthetic paths for preparation of sulfamethoxazole: 4-nitrozo-N-(5-methy-3-isoyazolyl)benzenesulfonamide (SMX-NO), 4-nitro-N-(5-methy-3-isoxazolyl) benzenesulfonamide (SMX-NO2), azoxybenzene-4,4-(N-5-methy-3-isoxazolyl)disulfonamide (SMX-AZ), N-(4-aminobenzenesulfoniyl)-3-oxo-butyramidine (SMX-AD) and 4-hydroxylamino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide (SMX-HA). Such compounds may be useful in the development of rapid, accurate diagnostic tests for hypersensitivity of sulfamethoxazole.
sulfamethoxazole; metabolite; synthesis
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Podaci o prilogu
160-x.
1998.
objavljeno
Podaci o matičnoj publikaciji
Abstract book
Paoletti, R.
Milano: Fondazione Giovani Lorenzini, Milano, Italija; Giovanni Medical
Podaci o skupu
Fourth European Congress of Pharmaceutical Sciences
poster
11.09.1998-13.09.1998
Milano, Italija