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Microbial resistance by ribosomal methylases revisited (CROSBI ID 522281)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Maravić, Gordana Microbial resistance by ribosomal methylases revisited // Central European Symposium on Antimicrobial Resistance, Book of abstracts. 2006. str. 22-x

Podaci o odgovornosti

Maravić, Gordana

engleski

Microbial resistance by ribosomal methylases revisited

Methylation is the most frequent posttranscriptional modification found in rRNA, exerted mostly by S-adenosyl-methionine dependent methylases. Furthermore, in addition to the essential set of enzymes, some antibiotic producing bacteria as well as ever growing number of antibiotic resistant strains contain different rRNA methylases, which protect their protein synthesis machinery from the destructive action of ribosomal antibiotics. Most widespread resistance problem is caused by Erm methylases that generate the resistance to macrolide antibiotics by methylation of a single adenine residue within the 23S rRNA. Another worrying example has been found among 16S rRNA methylases from the Agr family. Until recently these enzymes were restrained to antibiotic producers only, but they are now found to be spreading among clinical strains by rapid horizontal transfer. Erm methylases have been studied for a number of years and are considered as biochemically and genetically well characterised enzymes. On the other side, we are only getting to know the characteristic features of Agr methylases. The mechanism of action of Erm and Agr enzymes will be discussed, known data and new findings will be put in perspective, with special attention to potential solutions of ribosomal antibiotic resistance problem.

antibiotics; resistance; ribosomal methylases

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Podaci o prilogu

22-x.

2006.

objavljeno

Podaci o matičnoj publikaciji

Central European Symposium on Antimicrobial Resistance, Book of abstracts

Podaci o skupu

Central European Symposium on Antimicrobial Resistance

pozvano predavanje

18.06.2006-21.06.2006

Visoke tatre, Slovačka

Povezanost rada

Biologija