Microbial resistance by ribosomal methylases revisited (CROSBI ID 522281)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Maravić, Gordana
engleski
Microbial resistance by ribosomal methylases revisited
Methylation is the most frequent posttranscriptional modification found in rRNA, exerted mostly by S-adenosyl-methionine dependent methylases. Furthermore, in addition to the essential set of enzymes, some antibiotic producing bacteria as well as ever growing number of antibiotic resistant strains contain different rRNA methylases, which protect their protein synthesis machinery from the destructive action of ribosomal antibiotics. Most widespread resistance problem is caused by Erm methylases that generate the resistance to macrolide antibiotics by methylation of a single adenine residue within the 23S rRNA. Another worrying example has been found among 16S rRNA methylases from the Agr family. Until recently these enzymes were restrained to antibiotic producers only, but they are now found to be spreading among clinical strains by rapid horizontal transfer. Erm methylases have been studied for a number of years and are considered as biochemically and genetically well characterised enzymes. On the other side, we are only getting to know the characteristic features of Agr methylases. The mechanism of action of Erm and Agr enzymes will be discussed, known data and new findings will be put in perspective, with special attention to potential solutions of ribosomal antibiotic resistance problem.
antibiotics; resistance; ribosomal methylases
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Podaci o prilogu
22-x.
2006.
objavljeno
Podaci o matičnoj publikaciji
Central European Symposium on Antimicrobial Resistance, Book of abstracts
Podaci o skupu
Central European Symposium on Antimicrobial Resistance
pozvano predavanje
18.06.2006-21.06.2006
Visoke tatre, Slovačka