Effect of botulinum toxin type A on hyperalgesia alloxan and streptozotocin induced diabetic neuropathy (CROSBI ID 525009)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Lacković, Zdravko ; Bach-Rojecky, Lidija ; Šalkovic-Petrišić, Melita
engleski
Effect of botulinum toxin type A on hyperalgesia alloxan and streptozotocin induced diabetic neuropathy
Recently we found that botulinum toxin type A (BTX-A) reduced pain hypersensitivity in rats with surgical neuropathy (Bach-Rojecky at al. J. Neural Transm 2005 ; 112:215). Here we report that BTX-A has antinociceptive activity in diabetic neuropathy, too. Adult male Wistar rats were made diabetic by subcutaneous injection of alloxan or streptozotocin. After 5 days only animals with a tail-vein blood-glucose concentration of above 15 mmol/l were considered diabetic and included in the study. Paw-pressure and hot plate tests were first performed 3 weeks following betacitotoxic injection. Only the animals with significantly different mechanical thresholds compared to control group were considered neuropathic (hyperalgesic) and were than subjected to BTX-A treatment. On day 5 after BTX-A 5 and 7 U/kg treatment significant antinociceptive effect was observed i.e. diminished number of flinches and shakes of the formalin-injected paw. The lowest used dose (3 U/kg) was ineffective. With the paw pressure test results were practically the same. To our knowledge this is the first demonstration that a single peripheral injection of BTX might have antinociceptive effect in diabetic neuropathy.
botulinum toxin type A; neuropathic pain; antinociception; diabetes mellitus
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
312-312.
2006.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Acta pharmacologica Sinica
Vanhoute, Paul M.
Peking: Chinese Pharmacological Society
1671-4083
Podaci o skupu
World Congress of Pharmacology (15 ; 2006)
poster
02.07.2006-07.07.2006
Peking, Kina
Povezanost rada
Temeljne medicinske znanosti