Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis (CROSBI ID 137548)
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Gornik, Olga ; Gornik, Ivan ; Gašparović, Vladimir ; Lauc, Gordan
engleski
Change in transferrin sialylation is a potential prognostic marker for severity of acute pancreatitis
Early prediction of severe acute pancreatitis is one of the problems in clinical practice. Since many diseases are associated with alteration in glycosylation, in this work we studied sialylation of transferrin and serum proteins in acute pancreatitis. Sialylation was analyzed during first eight days of hospitalization of 30 patients and compared to 30 healthy controls. Transferrin sialylation was measured using enzyme linked lectin assay, while sialic acid on proteins was measured using resorcinol method. Both analyzed parameters changed during studied period. The change in transferrin sialylation between Day1 and Day2 of hospitalization was shown to be early prognostic marker of acute pancreatitis, with better sensitivity (88.9%) and specificity (90.5%) than other markers tested. Sialylation of transferrin and total serum proteins reflects the intensity of inflammatory response during acute pancreatitis and could be used as prognostic parameter for disease severity.
acute pancreatitis; sialylation; transferrin; glycosylation; serum proteins; prognostic marker
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Povezanost rada
Temeljne medicinske znanosti, Biologija