A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives (CROSBI ID 541951)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Rajić, Zrinka ; Jadrijević-Mladar Takač, Milena ; Vinković, Marijana ; Zorc, Branka ; Takač, Vedran
engleski
A Study of H-Bond in Group of NSAID Hydroxamic Acid Derivatives
The conformational behaviour of NSAID series (ibuprofen, fenprofen, ketoprofen, diclophenac and indomethacin) monohydroxamic acids and their intermediates have been studied in DMSO-d6 solution by one- and two-dimesional homo and heteronuclear 1H and 13C NMR spectroscopy and in solid state using FTIR spectroscopy. Significant hydrogen bonding effects were observed in both, solid state and solutions. The NMR spectra (1H and 13C NMR, COSY, NOESY, HMBC, HETCOR) revealed that investigated NSAID hydroxamic acids and their corresponding intermediates in DMSO solution are in keto form of cis-(Z) conformer with intramolecular hydrogen bond O-H...O= type. NMR findings observed in DMSO-d6 solution are in good agreement with FTIR of NSAID hydroxamic acids in solid state.
Hydrogen bond; NSAID hydroxamic acis; NMR spectroscopy; one- and two-dimensional homo and heteronuclear 1H and 13C NMR; IR spectroscopy
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Podaci o prilogu
14-14.
2008.
objavljeno
Podaci o matičnoj publikaciji
CEUM 2008 Book of Abstracts: The 10th Central European NMR Symposium & The 10th Central European Bruker NMR Users Meeting
Vilko Smrečki
Zagreb: Institut Ruđer Bošković
978-953-6690-77-0
Podaci o skupu
The 10th Central European NMR Symposium & The 10th Central European Bruker NMR Users Meeting
poster
29.09.2008-30.09.2008
Zagreb, Hrvatska