Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations (CROSBI ID 145097)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Perković, Ivana ; Butula, Ivan ; Zorc, Branka ; Hock, Karlo ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; De Clercq, Erik ; Balzarini, Jan ; Mintas, Mladen
engleski
Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations
The novel hydroxyurea derivatives of l- and d-amino acid amides 5a– l were prepared by aminolysis of N-(1-benzotriazolecarbonyl)-amino acid amides 4a– f with O-benzylhydroxylamine and N-methylhydroxylamine and evaluated for their antiviral and cytostatic activity against malignant tumor cell lines and normal human fibroblasts. Compounds 5a, 5c, 5e and 5k showed the highest antiproliferative effects against all tumor cell lines tested. The strongest non-specific cytostatic activities against HeLa cells were affected by compounds 5a, 5c, 5e and 5k on MCF-7 cells by 5c, 5e and 5k and MIA PACa-2 cells by 5c and 5k. Differential effects at micromolar concentrations were observed for compounds 5a, 5c, 5e, 5k and 5l in Hep G2 cells, for compounds 5c, 5e, 5k and 5l in PC-3 cells and for compounds 5e, 5k and 5l in SW 620 cells.
antiviral activity; cytostatic activity; human tumor cell lines; hydroxyureas
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Podaci o izdanju
71 (6)
2008.
546-553
objavljeno
1747-0277
10.1111/j.1747-0285.2008.00660.x
Povezanost rada
Kemija, Temeljne medicinske znanosti, Farmacija