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Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations (CROSBI ID 145097)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Perković, Ivana ; Butula, Ivan ; Zorc, Branka ; Hock, Karlo ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; De Clercq, Erik ; Balzarini, Jan ; Mintas, Mladen Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations // Chemical biology & drug design, 71 (2008), 6; 546-553. doi: 10.1111/j.1747-0285.2008.00660.x

Podaci o odgovornosti

Perković, Ivana ; Butula, Ivan ; Zorc, Branka ; Hock, Karlo ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir ; De Clercq, Erik ; Balzarini, Jan ; Mintas, Mladen

engleski

Novel Lipophilic Hydroxyurea Derivatives: Synthesis, Cytostatic and Antiviral Activity Evaluations

The novel hydroxyurea derivatives of l- and d-amino acid amides 5a– l were prepared by aminolysis of N-(1-benzotriazolecarbonyl)-amino acid amides 4a– f with O-benzylhydroxylamine and N-methylhydroxylamine and evaluated for their antiviral and cytostatic activity against malignant tumor cell lines and normal human fibroblasts. Compounds 5a, 5c, 5e and 5k showed the highest antiproliferative effects against all tumor cell lines tested. The strongest non-specific cytostatic activities against HeLa cells were affected by compounds 5a, 5c, 5e and 5k on MCF-7 cells by 5c, 5e and 5k and MIA PACa-2 cells by 5c and 5k. Differential effects at micromolar concentrations were observed for compounds 5a, 5c, 5e, 5k and 5l in Hep G2 cells, for compounds 5c, 5e, 5k and 5l in PC-3 cells and for compounds 5e, 5k and 5l in SW 620 cells.

antiviral activity; cytostatic activity; human tumor cell lines; hydroxyureas

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Podaci o izdanju

71 (6)

2008.

546-553

objavljeno

1747-0277

10.1111/j.1747-0285.2008.00660.x

Povezanost rada

Kemija, Temeljne medicinske znanosti, Farmacija

Poveznice
Indeksiranost