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Macromolecular prodrugs. VIII. synthesis of polymer-gemfibrozil conjugates

Gemfibrozil is covalently linked to two similar polymers: poly[a,b-(N-2-hydroxyethyl-DL-aspartamide)] and poly[a,b-(N-3-hydroxypropyl-DL-aspartamide)]. The synthesised polymer-drug conjugates differ in average molecular mass, type of covalent bonding, length of spacer, drug-loading and solubility.

gemfibrozil; macromolecular prodrug; polymer-drug conjugate; poly[a;b-(N-2-hydroxyethyl-DL-aspartamide)]; poly[a;b-(N-3-hydroxypropyl-DL-aspartamide)]; poly-DL-(2;5-dioxo-1;3-pyrrolidinediyl)

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