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Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans (CROSBI ID 161569)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Knežević, Ana ; Gornik, Olga ; Polašek, Ozren ; Pučić, Maja ; Redžić, Irma ; Novokmet, Mislav ; Rudd, Pauline M ; Wright, Alan F. ; Campbell, Harry ; Rudan, Igor et al. Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans // Glycobiology, 20 (2010), 8; 959-969

Podaci o odgovornosti

Knežević, Ana ; Gornik, Olga ; Polašek, Ozren ; Pučić, Maja ; Redžić, Irma ; Novokmet, Mislav ; Rudd, Pauline M ; Wright, Alan F. ; Campbell, Harry ; Rudan, Igor ; Lauc, Gordan

engleski

Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans

Protein glycosylation affects nearly all molecular interactions at the cell surface and in the intercellular space. Many of the physiological variations which are part of homeostatic mechanisms influence glycosylation. However, a comprehensive overview of changes in glycosylation caused by aging and common lifestyle parameters is still lacking. After analyzing N-glycans in plasma of 1, 914 individuals from Croatian islands of Vis and Korčula we performed a comprehensive analysis of the dependence of different glycosylation features (position of fucose, level of galactosylation, sialylation and branching) on aging, smoking, body fat and plasma lipid status. A number of statistically significant associations were observed. Glycosylation changes with aging were especially evident in females, mostly in association with the transition from pre-menopausal to post-menopausal age. Levels of core fucosylated, nongalactosylated, digalactosylated and disialylated biantennary glycans were shown to be mainly age dependent, but the level of branching and higher levels of galactosylation were found to correlate with lipid status. For the majority of glycans which we analyzed all examined parameters explained up to 5% of the variance. The only notable exception were nongalactosylated glycans where 20% of the variance was explained, mostly by age and blood pressure. In general, only a small fraction of the variability in glycan levels observed in a population was explained by age and other measured parameters, indicating that even in the absence of a genetic template, glycan levels are mostly determined by genetic background and/or specific pathophysiological processes.

N-glycans; human plasma glycome; ageing; body fat; smoking

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Podaci o izdanju

20 (8)

2010.

959-969

objavljeno

0959-6658

Povezanost rada

Temeljne medicinske znanosti, Biologija

Indeksiranost