engleski

PARAOXONASE POLYMORPHISMS AND PLATELET ACTIVATING FACTOR ACETYLHYDROLASE ACTIVITY AS A GENETIC RISK FACTORS IN CEREBRAL ATHEROSCLEROSIS

The results of the present study show that basal and stimulated PON1 activities were significantly decreased in patient’s group with cerebrovascular stenosis ( group of patients with symptoms of cerebrovascular insufficiency and stenosis of carotid artery more than 50% of the lumen) versus control no-stenosis group (p<0.05). There were no statistically significant relationships between PON1 activity and lipid parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol and tryacilglycerols), p>0.05. According to the obtained results the decreased PON1 activities in patients with cerebrovascular stenosis may cause decreased HDL antioxidant capacity and therefore contribute to the increase risk of the development of cerebrovascular atherosclerosis.However, there were no significant differences in genotype or allele frequencies of pon1 and pon2 genes between patients with stenosis of cerebral arteries and no-stenosis control group indicating that changes in paraoxonase activity are determined by both genetic and environmental factors. Our results show the most significant linear relationship between PAF-AH activity and total cholesterol and LDL-cholesterol ( p<0.001) in control no-stenosis group as well as in the group of patients with cerebrovascular stenosis. The median serum PAF-AH activity did not differ significantly between patients with cerebrovascular stenosis and control no-stenosis group (p>0, 05) while LDL standardized PAF-AH activity showed significant difference between both examined groups (p<0.0001). According to our results the LDL-standardized PAF-AH activity could be used as an additional discriminating biochemical indicator of cerebrovascular stenosis.

cerebrovascular atherosclerosis, basal and stimulated PON1 activities, Paraoxonase polymorphisms determinations, PAF-AH activity

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