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Role of phosholipid vesicles and vehicle composition in local delivery of diclofenac sodium

Conventional soy lecithin liposomes, deformable liposomes as well as PG-liposomes containing 10-30% of propylene glycol were prepared and compared with each other for the physicochemical properties. The characterization of the liposomes was based on balancing the size, the polidispersity, the zeta potential and the entrapment of diclofenac sodium. Regarding the size, PG-liposomes had significantly bigger mean diameter relative to conventional and deformable liposomes, proportionally to the propylene glycol content. Conventional and deformable liposomes were of similar zeta potential, while PG-liposomes showed slightly more negative zeta potential values. The highest entrapment of diclofenac sodium was achieved by PG-liposomes containing 30% of propylene glycol. In addition, all of the investigated various types of liposomes were prepared at two different phospholipid concentrations, whereat formulations with higher phospholipid content showed increased entrapment efficiency. Considering transdermal delivery, the next steps would involve permeability of the entrapped drug from different phospholipid vesicles through the skin.

Conventional liposomes; Deformable liposomes; PG-liposomes; Physicochemical characterization; Diclofenac sodium

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