engleski

Development and in vitro evaluation of a vaginal delivery system for acyclovir

Acyclovir was entrapped in liposomes prepared by polyol dilution method, whereby different phospholipid compositions were used (EPC, EPC/SA=9/3 and EPC/EPG=9/1, molar ratio). All liposomal preparations were characterised for particle size, entrapment efficiency and tested for in vitro stability in buffer pH 4.5 (corresponding to normal human vaginal pH), as well as in vaginal fluid simulant (medium developed to simulate the fluid produced in the human vagina).

acyclovir; liposomes; stability

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