Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Glycans are a novel biomarker of chronological and biological age (CROSBI ID 614718)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Krištić, Jasminka ; Vučković, Frano ; Menni, Cristina ; Klarić, Lucija ; Keser, Toma ; Beceheli, Ivona ; Pučić-Baković, Maja ; Novokmet, Mislav ; Mangino, Massimo ; Thaqi, Kujtim et al. Glycans are a novel biomarker of chronological and biological age // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules", HDBMB2014 / Katalinić, Maja ; Kovarnik, Zrinka (ur.). Hrvatsko Društvo za Biotehnologiju, 2014. str. 103-103

Podaci o odgovornosti

Krištić, Jasminka ; Vučković, Frano ; Menni, Cristina ; Klarić, Lucija ; Keser, Toma ; Beceheli, Ivona ; Pučić-Baković, Maja ; Novokmet, Mislav ; Mangino, Massimo ; Thaqi, Kujtim ; Rudan, Pavao ; Novokmet, Natalija ; Šarac, Jelena ; Missoni, Saša ; Kolčić, Ivana ; Polašek, Ozren ; Rudan, Igor ; Campbell, Harry ; Hayward, Caroline ; Aulchenko, Yurii ; Valdes, Ana ; Wilson, James F ; Gornik, Olga ; Primorac, Dragan ; Zoldoš, Vlatka ; Lauc, Gordan

engleski

Glycans are a novel biomarker of chronological and biological age

Fine structural details of glycans attached to the conserved N-glycosylation site significantly affect function of individual IgG molecules, but also mediate inflammation at the systemic level. By analysing IgG glycosylation in 5117 individuals from four European populations we have revealed very complex patterns of changes of IgG glycosylation with age. Several IgG glycans (including FA2B, FA2G2, FA2BG2) changed considerably with age and the combination of these three glycans can explain up to 58% of variance in chronological age, significantly more than other markers of biological age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus IgG glycosylation appears to be closely linked with both chronological and biological age. Considering the important role of IgG glycans in inflammation, and since the observed changes with age promote inflammation, changes in IgG glycosylation also seem to represent a factor contributing to aging.

Aging ; Glycome ; Glycosylation ; Immunoglobulin G ; Inflammation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

103-103.

2014.

objavljeno

Podaci o matičnoj publikaciji

Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules", HDBMB2014

Katalinić, Maja ; Kovarnik, Zrinka

Hrvatsko Društvo za Biotehnologiju

978-953-95551-5-1

Podaci o skupu

The Interplay of Biomolecules, HDBMB2014

poster

24.09.2014-27.09.2014

Zagreb, Hrvatska; Zadar, Hrvatska

Povezanost rada

Biologija