Spectroscopic Characterization and Biological Activity of Fatty Hydroxamic Acids Derived from Olive Oil Triacylglycerides (CROSBI ID 615842)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
BARBARIĆ, MONIKA ; VIKIĆ-TOPIĆ, DRAŽEN ; MARINIĆ, ŽELJKO ; VOJTA, DANIJELA ; ZOVKO KONČIĆ, MARIJA ; MIŠKOVIĆ, KATARINA ; BAUS LONČAR, MIRELA ; JADRIJEVIĆ-MLADAR TAKAČ, MILENA
engleski
Spectroscopic Characterization and Biological Activity of Fatty Hydroxamic Acids Derived from Olive Oil Triacylglycerides
Fatty hydroxamic acid (FHAs) mixture, composed mainly of oleoyl and linoleyl hydroxamic acid (OHA and LHA respectively), was derived from olive oil triacylglycerides (Scheme). The FHAs mixture was elucidated by means of IR, Raman, MS, one- and two-dimensional homo- and heteronuclear 1H and 13 C-NMR spectroscopy in comparison with corresponding olive oil spectra. The ratio of the OHA and LHA (4:1) was confirmed by MALDI-TOF/TOF mass spectrometry.The results of FHAs cell toxicity on normal fibroblast (BJ) and tumour cell linee (HeLa) revealed that the normal cell line was sensitive to FHAs in whole range of applied concentrations while HeLa tumor cell line was sensitive only at higher FHAs concentrations.The radical scavenging, metal chelating and the antioxidant activity in β- carotene-linoleate assay, as well as the reducing power of FHAs, gave positive results of FHAs activity in these tests. The ADMET predictor parameters revealed that the FHAs in comparison to their corresponding carboxylic precursors (oleic and linoleic acids) are more prominent as leading compound for further research.
Fatty hydroxamic acids; synthesis; IR; Raman; NMR and MS spectroscopy; antioxidant activity; cytotoxic activity; ADMET
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Podaci o prilogu
11-11.
2014.
objavljeno
Podaci o matičnoj publikaciji
Program and Book of Abstracts - CEUM 2014
Vilko Smrečki and Dražen Vikić-Topić
Zagreb: Institut Ruđer Bošković
978-953-7941-03-01
Podaci o skupu
16th Central European NMR Symposium and 16 th Central European Bruker NMR Users
poster
16.10.2014-17.10.2014
Zagreb, Hrvatska