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izvor podataka: crosbi

Gemfibrozil ester and amide derivatives - synthesis, spectroscopic characterisation and QSPR (CROSBI ID 211535)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lovrek, Monika ; Jadrijević-Mladar Takač, MIlena ; Zorc, Branka ; Boneschans, Banie Gemfibrozil ester and amide derivatives - synthesis, spectroscopic characterisation and QSPR // Die Pharmazie, 55 (2000), 11; 811-816

Podaci o odgovornosti

Lovrek, Monika ; Jadrijević-Mladar Takač, MIlena ; Zorc, Branka ; Boneschans, Banie

engleski

Gemfibrozil ester and amide derivatives - synthesis, spectroscopic characterisation and QSPR

Synthesis and spectroscopic characterisation of different gemfibrozil esters 3 and amides 4 is described. In the first step gemfibrozil reacted with N-1-benzotriazole carboxylic acid chloride (1) providing gemfibrozil benzotriazolide (2). Compound 2 readily reacted with alcohols and amines forming corresponding esters 3 and amides 4, potential prodrugs of a well known hypolipaemic drug gemfibrozil. The quantitative structure property relationship (QSPR) in the series of gemfibrozil esters and amides was studied. The following topological descriptors and physicochemical parameters were used: Wienner number (W), connectivity index (1cv), relative molecular mass (Mr), van der Waals volume (Vw) and parameters of lipophilicity (log P and RM).

Gemfibrozil; Amide; Synthesis; QSPR

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Podaci o izdanju

55 (11)

2000.

811-816

objavljeno

0031-7144

Povezanost rada

Kemija, Farmacija

Indeksiranost