Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

1, 3-Benzoxazin-2, 4-dione and 1, 4-Benzoxazin-2, 3-dione Derivatives (CROSBI ID 617818)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Movrin, Marija ; Maysinger, Dušica ; Jadrijević-Mladar, Milena 1, 3-Benzoxazin-2, 4-dione and 1, 4-Benzoxazin-2, 3-dione Derivatives // FIP-85 Abstracts, Programme of Oral and Poster Communications, 45th International Congress of Pharmaceutical Sciences / - (ur.). Montréal: -, 1985. str. 173-173

Podaci o odgovornosti

Movrin, Marija ; Maysinger, Dušica ; Jadrijević-Mladar, Milena

engleski

1, 3-Benzoxazin-2, 4-dione and 1, 4-Benzoxazin-2, 3-dione Derivatives

A series of 1, 3-benzoxazin, 2, 4-diones and 1, 4-benzoxazin-2, 3-diones have been synthesized and then tested for their antimitotic and antimicrobial activity. Benzoxazin-diones were prepared by oxidation of isatin and 5-nitro-isatin. Acting as H-active hetercyclic compounds benzoxazin-diones were either aminomethylated or condensed with monosubstituted hydrazines, thiosemicarbazide and several aromatic amines and subsequently aminomethylated. In vitro studies of the synthesized compounds with incorporated basic side chains similar to alkilating agents showed considerably antimitotic activity. The compounds with an aminoacid side chains were also active. Mannich bases with D, L-alanine proved to be more active than those ones containing L-alanine. The glycinamide analogue showed significantly higher mitodepressant activity than the corresponding glycine-ester derivative. The same benzoxazine derivatives tested against variety of standard microorganisms exhibited only weak bacteriostatic activity. It is interesting to note that the increase in relative molecular mass of the synthesized compounds is correlated reasonably well with the theoretically calculated topological indices.

1; 3-Benzoxazin-2; 4-diones; 1; 4-Benzoxazin-2; 3-diones; Synthesis; Biological activity; Topological indices; QSAR

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

173-173.

1985.

objavljeno

Podaci o matičnoj publikaciji

FIP-85 Abstracts, Programme of Oral and Poster Communications, 45th International Congress of Pharmaceutical Sciences

-

Montréal: -

Podaci o skupu

45th International Congress of Pharmaceutical Sciences

poster

02.09.1985-06.09.1985

Montréal, Kanada

Povezanost rada

Farmacija