A New Route to Substituted N-hydroxyurea Derivatives (CROSBI ID 618103)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Jadrijević-Mladar Takač, Milena ; Butula, Ivan
engleski
A New Route to Substituted N-hydroxyurea Derivatives
The reaction of (1, Bz = benzyl) with fosgene (i) gave 1, 3, 5-(tribenzyloxy)biuret (2), whereas with BtCOCl (Bt = benzotriazolyl) (ii) gave 1-(N-benzyloxy)carbamoylbenzotriazole (5). Compounds 2 and 5 were reduced to their corresponding hydroxyl derivatives 3 and 6 (iii). The 5 and 6 were melted in presence of imidazole to afford 1, 3, 5-triazine-2, 4, 6(1H, 3H, 5H)-triones 7, X = -CON(OBz)CO-, and 8, Y = -CON(OH)CO- (iv). Scheme. Compounds 5, 6 or 7 in the reaction with ChNH2 (Ch = cyclohexyl) gave O- and/or N-substituted N-hydroxyureas 9 and 10 (v), whereas 8, due to its acidic properties, rather form cyclohexylamine salt.
N-Hydroxyura; Synthesis; Benzotriazole; 1; 3-5-Tribenzyloxy-biuret; 1-(N-benzyloxycarbamoylbenzotriazole; 1; 3; 5-Triazine-2; 4; 5(1H; 3H; 5H)-triones
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Podaci o prilogu
S111-S112.
2000.
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objavljeno
Podaci o matičnoj publikaciji
European journal of pharmaceutical sciences
Linden, H. Hans
Oxford: Elsevier
0928-0987
Podaci o skupu
6th European Congress on Pharmaceutical Sciences, EUFEPS 2000
poster
16.09.2000-19.09.2000
Budimpešta, Mađarska