engleski

Glycosilation profile of immunoglobulin G in moderate kidney dysfunction

Glycans constitute the most abundant and diverse form of the post-translational modifications. Here we explore the associations between IgG glycans and renal function in 3274 individuals from TwinsUK. We analyzed the correlation between renal function measured as eGFR and 76N-glycan traits using linear regressions adjusting for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. 14 glycan traits were associated with renal function in the discovery sample (P<6.5×10−4) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation and level of bisecting N- acetylglucosamine (GlcNAc) of the IgG glycans. This is the first study to show the role of IgG glycosylation in assessing kidney function. These results provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets.

clinical nephrology ; glycosylation ; renal function decline

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