Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

The Association Between Low Back Pain and Composition of IgG Glycome (CROSBI ID 230913)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Freidin, Maxim B. ; Keser, Toma ; Gudelj, Ivan ; Štambuk, Jerko ; Vučenović, Dunja ; Allegri, Massimo ; Pavić, Tamara ; Šimurina, Mirna ; Fabiane, Stella M. ; Lauc, Gordan et al. The Association Between Low Back Pain and Composition of IgG Glycome // Scientific reports, 6 (2016), 26815, 11. doi: 10.1038/srep26815

Podaci o odgovornosti

Freidin, Maxim B. ; Keser, Toma ; Gudelj, Ivan ; Štambuk, Jerko ; Vučenović, Dunja ; Allegri, Massimo ; Pavić, Tamara ; Šimurina, Mirna ; Fabiane, Stella M. ; Lauc, Gordan ; Williams, Frances M.K.

engleski

The Association Between Low Back Pain and Composition of IgG Glycome

Low back pain (LBP) is a common debilitating condition which aetiology and pathogenesis are poorly understood. We carried out a first so far analysis of associations between LBP and plasma IgG N-glycome in a sample of 4511 twins from TwinsUK database assessed for LBP, lumbar disc degeneration (LDD) as its possible cause, and IgG- glycan levels. Using weighted correlation network analysis, we established a correlation between LBP and glycan modules featured by glycans that either promote or block antibody-dependent cell-mediated cytotoxicity (ADCC). The levels of four glycan traits representing two of those modules were statistically significantly different in monozygotic twins discordant for LBP. Also, the trend to higher prevalence of systemic inflammatory disorders was shown for twins with low level of fucosylated glycans and high level of non-fucosylated glycans. Core fucosylation of IgG is a “safety switch” reducing ADCC, thus our results suggest the involvement of ADCC and associated inflammation in pathogenesis of LBP. No correlation between LDD scores and glycans was found assuming that the inflammation may not be a part of LDD. These data provide a new insight into understanding the complex pathophysiology of LBP and suggest glycan levels as a possible biomarker for inflammation-related subtypes of LBP.

Inflammation ; Molecular medicine ; Musculoskeletal system

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

6

2016.

26815

11

objavljeno

2045-2322

10.1038/srep26815

Povezanost rada

Biologija, Farmacija

Poveznice
Indeksiranost