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Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A (CROSBI ID 640057)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Drinovac, Višnja ; Bach-Rojecky, Lidija ; Matak, Ivica ; Lacković, Zdravko Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A. 2016

Podaci o odgovornosti

Drinovac, Višnja ; Bach-Rojecky, Lidija ; Matak, Ivica ; Lacković, Zdravko

engleski

Role of capsaicin-sensitive neurons in bilateral antinociceptive effect of botulinum toxin type A

Background and aims: Recently is suggested that botulinum toxin A (BTX-A) requires axonal transport from periphery to central nervous system through capsaicin-sensitive neurons to achieve specific antihyperalgesic and antiallodynic effect. The aim of this study was to investigate the effect of sciatic nerve capsaicin-sensitive fibers desensitization on, previously demonstrated, bilateral antinociceptive effect in a model of “mirror pain” induced by intramuscular carrageenan injection. Methods: 100μL 3% carrageenan (dissolved in saline) or saline was injected into right gastrocnemius muscle of male Wistar rats. Animals which developed bilateral mechanical allodynia two weeks following carrageenan injection were divided into following groups (5-6 animals per experimental group): (1) and (2) saline or BTX (5U/kg) intraplantar (subcutaneously into the right hind-paw pad), (3) and (4) vehiculum or capsaicin perisciatic (15 min ; right sciatic nerve), (5) and (6) BTX-A + capsaicin or vehiculum perisciatic. Nociceptive measurements were performed using von Frey filaments. Results: Unilateral BTX-A decreased mechanical hypersensitivity not only on ipsilateral (p<0.05), but on the contralateral side as well (p<0.05). In contrast, ipsilateral perineural capsaicin decreased mechanical hypersenitivity only at the side of pain induction (p<0.01). In combination with BTX-A, we observed no additive or synergistic ipsilateral effects. Ipsilateral capsaicin did not affect contralateral BTX-A's effect. Conclusions: Presented results support recent findings that central antinociceptive effect of BTX-A might be associated with the activity of capsaicin-sensitive neurons in the area of sciatic innervation, since capsaicin and BTX-A had no additive/synergistic antinociceptive effects. In addition, it distinguishes the bilateral versus unilateral effects of peripherally applied BTX-A and capsaicin which might be important in further understanding of “mirror pain” origin, as well as potential transcytosis of BTX-A in spinal circuits.

Botulinum toxin A; Mirror pain; Capsaicin-sensitive neurons

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Podaci o prilogu

2016.

objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

10th Forum of Neuroscience (FENS 2016)

poster

02.07.2016-06.07.2016

Kopenhagen, Danska

Povezanost rada

Temeljne medicinske znanosti, Farmacija