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Phytochemical evaluation of Thymus longicaulis in comparison with Thymus vulgaris (CROSBI ID 650507)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Kindl, Marija ; Bucar, Franz ; Blažeković, Biljana ; Bival Štefan, Maja ; Vladimir-Knežević, Sanda Phytochemical evaluation of Thymus longicaulis in comparison with Thymus vulgaris // Reviews on Clinical Pharmacology and Drug Therapy / Shabanov, Petr D. (ur.). Sankt Peterburg: ECO-vector, LLC, 2017. str. 13-13

Podaci o odgovornosti

Kindl, Marija ; Bucar, Franz ; Blažeković, Biljana ; Bival Štefan, Maja ; Vladimir-Knežević, Sanda

engleski

Phytochemical evaluation of Thymus longicaulis in comparison with Thymus vulgaris

Thymus longicaulis C. Presl (Lamiaceae) is a small aromatic perennial herb and a typical representative of the Illyric-Mediterranean flora. It is a traditional remedy for cold, flu, cough, nephritis and abdominal pain (1). This study was aimed to evaluate phytochemical composition of the aerial parts of T. longicaulis wild-growing in Croatia. In order to find the possibility of its use in modern phytotherapy, the results were compared with those obtained for T. vulgaris, as the officially recognised medicinal plant within the genus Thymus (2). The presence of phenolic acids and flavonoids in the methanolic extracts and terpenes from the essential oil was detected by TLC. Chromatographic profiles were established for the studied plant extracts by LC-ESI-MS/MS and RP-HPLC-DAD analysis. All detected phenolic acids belonged to derivatives of rosmarinic acid, while all identified flavonoids were flavons. Rosmarinic acid was found to be the most abundant polyphenolic constituent (48 mg/g) while among flavonoids luteolin-7-O-glucuronide was present with the highest concentration (14 mg/g). The extraction yield (V/m) of essential oil isolated by hydrodistillation was 1.7%. According to GC-MS analysis forty three compounds were identified, representing 99.7% of the total oil. The essential oil was characterised by a high percentage of the monoterpene fraction (95%) with a prevalence of oxygenated monoterpenes (61%). Thymol (43%), p-cymene (18%) and γ-terpinene (11%) were identified as the most abundant compounds. Owing to its phytochemical composition comparable to those of T. vulgaris, this medicinal plant could be considered as a new source of the pharmacopoeial herbal drugs Thymi herba and Thymi aetheroleum.

Thymus longicaulis ; phenolic acids ; flavonoids ; essential oil

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Podaci o prilogu

13-13.

2017.

objavljeno

Podaci o matičnoj publikaciji

Reviews on Clinical Pharmacology and Drug Therapy

Shabanov, Petr D.

Sankt Peterburg: ECO-vector, LLC

1683-4100

Podaci o skupu

The 21th International Congress "Phytopharm 2017" and 10th Anniversary of the TCM Research Center Graz

poster

02.07.2017-05.07.2017

Graz, Austrija

Povezanost rada

Farmacija