Profiling and genetic control of the murine immunoglobulin G glycome (CROSBI ID 250546)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Krištić, Jasminka ; Zaytseva, Olga O. ; Ram, Ramesh ; Nguyen, Quang ; Novokmet, Mislav ; Vučković, Frano ; Vilaj, Marija ; Trbojević-Akmačić, Irena ; Pezer, Marija ; Davern, Kathleen M. ; Morahan, Grant ; Lauc, Gordan
engleski
Profiling and genetic control of the murine immunoglobulin G glycome
Immunoglobulin G (IgG) glycosylation is essential for function of the immune system, but the genetic and environmental factors that underlie its inter- individual variability are not well defined. The Collaborative Cross (CC) genetic resource harnesses over 90% of the common genetic variation of the mouse. By analyzing the IgG glycome composition of 95 CC strains, we made several important observations: (i) glycome variation between mouse strains was higher than between individual humans, despite all mice having the same environmental influences ; (ii) five genetic loci were found to be associated with murine IgG glycosylation ; (iii) variants outside traditional glycosylation site motifs affected glycome variation ; (iv) bisecting N- acetylglucosamine (GlcNAc) was produced by several strains although most previous studies have reported the absence of glycans containing the bisecting GlcNAc on murine IgGs ; and (v) common laboratory mouse strains are not optimal animal models for studying effects of glycosylation on IgG function.
IgG glycosylation
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nije evidentirano
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Podaci o izdanju
14 (5)
2018.
516-524
objavljeno
1552-4450
1552-4469
10.1038/s41589-018-0034-3