engleski

Nifedipine and nifedipine-cyclodextrin complex in liposomes and microspheres

The drug dissolution rate and solubility were increased by formation of inclusion complexes of nifedipine with hydroxypropyl-beta-cyclodextrin. The drug and drug-cyclodextrin complexes were entrapped into lecithin liposomes and glutaraldehyde treated chitosan microspheres. Both the entrapment methods were suitable for achieving the controlled release products so as to be eventually applied for the preparation of novel delivery systems.

nifedipine ; nifedipine-cyclodextrin complexes ; liposomes ; microspheres

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