engleski

Determination of memantine sorption parameters in Croatian soil and sediment samples

Human and veterinary pharmaceuticals are known for their great effect and application in the treatment, prevention and suppression of various diseases. The increasing production and consummation of pharmaceuticals are becoming serious problem due to possible impact on environment and living organisms. They are recognized as a new type of pollutant whose fate in environment is little known. Sorption is an extremely important process because of its great influence on pharmaceutical fate in environment. It mainly depends on the type of solid matrices, physico-chemical properties of chemicals and environment conditions. In this paper, memantine, pharmaceutical used in treating mild to serious Alzheimer's disease, was studied. Since, it has been in use only a few decades, its impact on the environment is still unknown. Therefore, the purpose of this study was to experimentally determine the Kd values of memantine and influence of organic matter (KOC), as one of the parameters affecting the binding of the substance to a solid phase in five different natural soil and five different natural sediment samples from the territory of Republic of Croatia. Sample preparation of soils/sediments and batch sorption experiments were performed according to the OECD 106 Procedure [1]. The effects of contact time, ionic strength, pH and Gibbs free energy on the degree of sorption were also investigated. Sorption phenomena were described using linear, Freundlich and Jovanovich isotherms. Results show that sorption of memantine is spontaneous physical process, best described with the kinetic model of pseudo- second order. Sorption coefficient, Kd increased with increasing pH and organic content (%OC) and decreased with increasing ionic strength.

Memantine ; Soil and sediment samples ; Sorption study ; Sorption coefficient ; Influence of organic matter ; Ionic strength and pH study ; Kinetic study

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