Correlation between HLA-A and HLA-B gene polymorphism and the risk of uveitis in East Croatia (CROSBI ID 676656)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Suver Stević, Mirjana ; Ferenac Kiš, Marina ; Bugarin, Anđelka ; Krizmanić, Kristina ; Nemet- Gužvić, Renata ; Tokić, Stana ; Glavaš-Obrovac, Ljubica ; Samardžija, Marina ; Matić, Suzana ; Marczi, Saška
engleski
Correlation between HLA-A and HLA-B gene polymorphism and the risk of uveitis in East Croatia
Uveitis is inflammation of the middle layer of the eye which cause damage of vital eye tissue and can lead to permanent vision loss. This complex disease may be localized to the eye or may be associated with systemic diseases. Several studies reported polygenic correlation to uveitis phenotypes, with emphasis on the association of HLA with the development and clinical course of uveitis. The goal of this study was to investigate the HLA-A and HLA-B gene polymorphisms that might predispose to uveitis in East Croatia. The group of 38 patients (20 males, 18 females) aged 8-65 years (mean 39.1 ± 15.6 years) was HLA typed using a PCR-SSP method at low resolution level in the period of 2007-2018. HLA-A and -B gene frequencies in group of patients were calculated in regard to control group of healthy unrelated bone marrow donors from Croatia. Comparison was conducted using Fisher’s (two-tailed) exact test. In a group of patients, 11 different variants of HLA-A and 16 different variants of HLA-B gene were found. The most common were HLA-A*02 (33.78 %), -A*03 (14.86 %), -A*01 (12.16 %) and -A*24 (10.81 %) and HLA-B*44 (15.79 %), -B*27 (11.84 %), -B*35 (11.84 %), -B*51 (11.84 %) and -B*08 (9.21 %). The HLA-B*27 (GF 11.84 vs 6.21 ; OR 2.03) and HLA-B*44 (GF 15.97 vs 9.3 ; OR 1.83) showed positive association with uveitis with statistical significance close to 0.05 (p=0.054 and p=0.071, respectively). In contrast, HLA- A*68 (GF 0.00 vs 4.61 ; OR 0.14 ; p=0.049) indicated a potential protective role for uveitis development in population of East Croatia.
HLA, uveitis
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Podaci o prilogu
359-360.
2019.
nije evidentirano
objavljeno
10.1111/tan.13518
Podaci o matičnoj publikaciji
HLA
Marsh, Steven G. E
John Wiley & Sons
2059-2302
Podaci o skupu
33rd European Immunogenetics and Histocompatibility Conference
poster
08.05.2019-11.05.2019
Lisabon, Portugal
Povezanost rada
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti