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Correlation between HLA-A and HLA-B gene polymorphism and the risk of uveitis in East Croatia (CROSBI ID 676656)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Suver Stević, Mirjana ; Ferenac Kiš, Marina ; Bugarin, Anđelka ; Krizmanić, Kristina ; Nemet- Gužvić, Renata ; Tokić, Stana ; Glavaš-Obrovac, Ljubica ; Samardžija, Marina ; Matić, Suzana ; Marczi, Saška Correlation between HLA-A and HLA-B gene polymorphism and the risk of uveitis in East Croatia // HLA / Marsh, Steven G. E (ur.). 2019. str. 359-360 doi: 10.1111/tan.13518

Podaci o odgovornosti

Suver Stević, Mirjana ; Ferenac Kiš, Marina ; Bugarin, Anđelka ; Krizmanić, Kristina ; Nemet- Gužvić, Renata ; Tokić, Stana ; Glavaš-Obrovac, Ljubica ; Samardžija, Marina ; Matić, Suzana ; Marczi, Saška

engleski

Correlation between HLA-A and HLA-B gene polymorphism and the risk of uveitis in East Croatia

Uveitis is inflammation of the middle layer of the eye which cause damage of vital eye tissue and can lead to permanent vision loss. This complex disease may be localized to the eye or may be associated with systemic diseases. Several studies reported polygenic correlation to uveitis phenotypes, with emphasis on the association of HLA with the development and clinical course of uveitis. The goal of this study was to investigate the HLA-A and HLA-B gene polymorphisms that might predispose to uveitis in East Croatia. The group of 38 patients (20 males, 18 females) aged 8-65 years (mean 39.1 ± 15.6 years) was HLA typed using a PCR-SSP method at low resolution level in the period of 2007-2018. HLA-A and -B gene frequencies in group of patients were calculated in regard to control group of healthy unrelated bone marrow donors from Croatia. Comparison was conducted using Fisher’s (two-tailed) exact test. In a group of patients, 11 different variants of HLA-A and 16 different variants of HLA-B gene were found. The most common were HLA-A*02 (33.78 %), -A*03 (14.86 %), -A*01 (12.16 %) and -A*24 (10.81 %) and HLA-B*44 (15.79 %), -B*27 (11.84 %), -B*35 (11.84 %), -B*51 (11.84 %) and -B*08 (9.21 %). The HLA-B*27 (GF 11.84 vs 6.21 ; OR 2.03) and HLA-B*44 (GF 15.97 vs 9.3 ; OR 1.83) showed positive association with uveitis with statistical significance close to 0.05 (p=0.054 and p=0.071, respectively). In contrast, HLA- A*68 (GF 0.00 vs 4.61 ; OR 0.14 ; p=0.049) indicated a potential protective role for uveitis development in population of East Croatia.

HLA, uveitis

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Podaci o prilogu

359-360.

2019.

nije evidentirano

objavljeno

10.1111/tan.13518

Podaci o matičnoj publikaciji

HLA

Marsh, Steven G. E

John Wiley & Sons

2059-2302

Podaci o skupu

33rd European Immunogenetics and Histocompatibility Conference

poster

08.05.2019-11.05.2019

Lisabon, Portugal

Povezanost rada

Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti

Poveznice
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