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Epidemiology of invasive bacterial disease in children before and after the introduction of vaccination against Haemophilus influenzae type b (CROSBI ID 677207)

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Didović, Diana ; Papić, Neven ; Vrdoljak, Maja ; Butić, Iva ; Čeljuska Tošev, Elvira ; Knezović, Ivica ; Tešović, Goran Epidemiology of invasive bacterial disease in children before and after the introduction of vaccination against Haemophilus influenzae type b // 11th Croatian Congress of Clinical Microbiology and the 8th Croatian Congress for Infectious Diseases Poreč, Hrvatska, 20.09.2016-23.09.2016

Podaci o odgovornosti

Didović, Diana ; Papić, Neven ; Vrdoljak, Maja ; Butić, Iva ; Čeljuska Tošev, Elvira ; Knezović, Ivica ; Tešović, Goran

engleski

Epidemiology of invasive bacterial disease in children before and after the introduction of vaccination against Haemophilus influenzae type b

Introduction: H. influenzae type b, S. pneumoniae and N. meningitidis were the leading causative agents of invasive bacterial diseases (IBD) among children of less than 5 years of age prior to the introduction of the H. influenzae type b conjugate vaccine. A significant decrease of invasive H. influenzae diseases (IHD) occured in nations that implemented routine Hib vaccination in their national immunization program (NIP). Aim: The goal of this study was to describe the frequency and characteristics of pediatric patients with IBD before and after implementation of routine Hib vaccination was implemented into the Croatian NIP. Subjects and methods: A retrospective analysis of administrative databases at University Hospital for Infectious Diseases “Dr. Fran Mihaljević”. Results: A total of 1112 pediatric patients’ (from 0 to 18 years of age) records with etiologically- proven IBD were analyzed. The patients were divided into three periods: first (reference) period prior to Hib vaccine introduction and two postvaccinal periods. During the second period, a statistically significant change in proportion occured for N. meningitidis (p<0, 05), S. agalactiae (p<0, 05) and H. influenzae (p<0, 0001). H. influenzae (p<0, 0001) maintained this trend during the third period as well. Additionally, a decrease in Hib meningitis cases was noted (p<0, 0001). Conclusion: The implementation of Hib vaccine in the Croatian NIP led to a significant decrease of IHD. S. pneumoniae and N. meningitidis are still the leading causative agents of IBD and thus the introduction of adequate pneumococcal and meningococal vaccine in Croatian NIP should be considered.

epidemiology ; invasive bacterial disease ; children ; vaccination ; haemophilus influenzae type

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Podaci o skupu

11th Croatian Congress of Clinical Microbiology and the 8th Croatian Congress for Infectious Diseases

poster

20.09.2016-23.09.2016

Poreč, Hrvatska

Povezanost rada

Kliničke medicinske znanosti