engleski

Biochemical Differences Among Naturally Occurring HPV-16 E6 Variants

A number of Human papillomaviruses (HPVs) were shown to be associated with various human cancers. Of these cervical cancer is the most important disease. Whilst the HPV E6 and E7 oncoproteins are responsible for cancer development at different anatomical sites, it is also clear that there are differences of these two oncoproteins among the viral isolates. Good examples of this are HPV-16 E6 variants found in various geographical locations, shown to differ in their capacities to cause cancer. Interestingly, some of these variants are more frequently detected in cancers than the other variants, suggesting that they exhibit very important differences in their ability to induce malignancy. The aim of our studies is to investigate these different cancer- causing activities which are still largely poorly understood at the molecular level.

Human papillomavirus ; E6 oncoprotein ; E6 variants ; cancer ; transformation

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