engleski

An association between niacin skin flush response and plasma triglyceride levels in patients with schizophrenia

Objective: Phospholipase A2 activation triggers the release of arachidonic acid from membrane phospholipids, and this mechanism is reportedly involved in a variety of physiological processes, including dopaminergic neurotransmission, insulin secretion, and the skin flush response to the water- soluble B vitamin niacin. Individuals with schizophrenia frequently exhibit abnormal dopaminergic signaling, attenuated niacin-induced skin flushing, and disturbances of glucose and lipid metabolism. We previously demonstrated an attenuated skin flush response to niacin in patients with schizophrenia. In this study, we investigated whether this attenuated niacin flush response might be associated with plasma lipid and glucose concentrations in schizophrenia. To our knowledge, this is the first study to investigate the possible association between niacin skin flush response and plasma lipid and glucose concentrations. Patients and methods: Forearm skin response to patches containing niacin of 0.1M, 0.01M, 0.001M and 0.0001M concentrations in 78 patients was rated using the method of volumetric niacin response (VNR). Results: Niacin skin flush response did not significantly predict total cholesterol, LDL cholesterol, HDL cholesterol, or glucose levels (P > 0.05). We found that higher plasma triglyceride levels were associated with higher total VNR values (P < 0.05) and that total VNR accounted for approximately 10.4% of the triglyceride levels variability (R2 change = 0.104). We also observed higher triglyceride levels in patients with positive niacin skin flush responses (visual score ≥ 2) compared to in patients without niacin skin flushing reactions (visual score < 2) at the 5-minute interval at niacin concentrations of 0.1 and 0.01M, and at the 10- and 15-minute intervals at niacin concentration of 0.001M (P < 0.05). Conclusion: Our finding supports the link between niacin sensitivity and lipid metabolism in schizophrenia.

Arachidonic acid-signaling ; Niacin skin flush response ; Plasma glucose ; Plasma lipids ; Schizophrenia

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