Acute promyelocytic leukemia M3: cytomorphologic, immunophnenotypic, cytogenetic, and molecular variants (CROSBI ID 97818)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Sučić, Mirna ; Zadro, Renata ; Burazer, Brankica ; Labar, Boris ; Nemet, Damir ; Mrsić, Mirando ; Aurer, Igor ; Mrsić, Sanja ; Hitrec, Vlasta ; Boban, Dubravka ; Marković-Glamočak, Mirjana ; Batinić, Drago ; Užarević, Branka ; Stavljenić Rukavina, Ana
engleski
Acute promyelocytic leukemia M3: cytomorphologic, immunophnenotypic, cytogenetic, and molecular variants
Acute promyelocytic leukemia M3 is AML subtype characterized by proliferation of malignant promyelocytes with mature myeloid immunophenotype and atypical reciprocal translocation involving chromosome 15 and 17 /t(15 ; 17)(q22 ; q11)/ resulting in the fusion of retinoic acid receptor alpha (RAR alpha) on chromosome 17 and the putative factor PML. There are three M3 morphologic variants: typical hypergranular form, hypogranular and basophilic variant. However, some of patients have not specific translocation, or they have other cytogenetic abnormalities beside or without characteristic ones. The aim of the study was to compare morphologic, immunologic, cytogenetic and molecular characteristic of blasts in 15 patients with M3 treated in Clinical Hospital Zagreb, Zagreb, Croatia. In major M3 patients (13) blasts had typical hypergranular appearance with mature myeloid immunophenotype (HLA-DR, CD13+, CD33+). Typical translocation /t(15 ; 17)(q22 ; q11)/ was detected by cytogenetic analysis in 5 M3 patients but PML/RAR was positive in 11 out of 14 patients with RT-PCR. In one patient t(17 ; 17) was found, in 2 patients +8 one patient had also add (7)(q22) and -7. Patients with complete remission rate (13) became PML/RAR negative. Four of them reverted to PCR positivity and relapsed within 3 months.
acute promyelocytic leukemia ; M3 ; t(15 ; 17)(q22 ; q11) ; immunophenotype
Rad je kao poster, na hrvatskom jeziku, prezentiran i na skupu II. hrvatski kongres hematologa i transfuziologa s međunarodnim sudjelovanjem, održanom od 16-19.10.1999., Dubrovnik, Hrvatska ; sažetak je objavljen u Liječnički vjesnik. Supplement 121 (1999) str. 154-154 ; a na engleskom jeziku na skupu 17th International Meeting and 13th European Congress of Clinical Chemistry and Laboratory Medicine, održanom od 06.-11.06.1999., Firenza, Italija ; sažetak objavljen u 'Clinical chemistry and laboratory medicine' 2 (1999) (S) str. 216-216.
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Podaci o izdanju
11 (6)
2002.
941-950
objavljeno
1525-8165
10.1089/152581602321080600
Povezanost rada
Kliničke medicinske znanosti, Farmacija