Primaquine derivatives: Modifications of the terminal amino group (CROSBI ID 268497)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Zorc, Branka ; Perković, Ivana ; Pavić, Kristina ; Rajić, Zrinka ; Beus, Maja
engleski
Primaquine derivatives: Modifications of the terminal amino group
Numerous modifications of the well-known antimalarial drug primaquine, both at the quinoline ring and at the primary amino group, have been reported, mostly to obtain antimalarial agents with improved bioavailability, reduced toxicity and/or prolonged activity. Modifications of the terminal amino group were made with the main idea to prevent the metabolic pathway leading to inactive and toxic carboxyprimaquine (follow-on strategy), but also to get compounds with different activity (repurposing strategy). The modifications undertaken until 2009 were included in a review published in the same year. The present review covers various classes of primaquine N-derivatives with diverse biological profiles, prepared in the last decade by our research group as well as the others. We have summarized the synthetic procedures applied for their preparation and discussed the main biological results. Several hits for the development of novel antiplasmodial, anticancer, antimycobacterial and antibiofilm agents were identified.
Primaquine derivatives ; Antiplasmodial activity ; Antiproliferative activity ; Antibacterial activity ; Antibiofilm ; Antioxidative activity
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
182
2019.
111640
19
objavljeno
0223-5234
1768-3254
10.1016/j.ejmech.2019.111640
Povezanost rada
Farmacija, Interdisciplinarne prirodne znanosti, Kemija, Temeljne medicinske znanosti