engleski

Mononuclear cobalt, nickel and copper complexes with glycinamide: structural properties and biological activity

Glycinamide (HL) is the simplest amino acid amide, cheap and available and easily synthesized. In the CSD there are only six structures containing the glycinamide fragment: glycinamide hydrochloride, two rhodium complexes, a bimetallic (Mn, Cr) ferrimagnet, a ruthenium complex and an iridium complex. As a part of our ongoing research on investigation of metal complexes with amino acids and their derivatives, we report synthesis, solid-state characterization and antiproliferative activity of cobalt, nickel and copper complexes with glycinamide. In the cobalt(II) and nickel(II) complexes [M(H2O)2(HL)2]X2 (M = Co, Ni ; X = Cl, Br/Cl, I), the metal(II) cation is octahedrally coordinated by two glycinamide molecules in a cis-fashion and by two water molecules. In [CuCl2(HL)2] and [CuBr1.3Cl0.7(HL)2] the octahedral coordination environment around the Cu(II) ions consists of two N, O-bidentate glycinamide ligands in a trans-fashion and two halide ions. [Co(H2O)2(HL)2]Cl2 and [CuCl2(HL)2] showed moderate antiproliferative activity and selectivity towards MCF-7 cell lines. The research was supported by the Croatian Science Foundation, project “Essential metal ions in Helicobacter pylori proteins and model complexes structure and function/property” (HRZZ-IP-2014-09-4274).

glycinamide ; cobalt ; nickel ; copper

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