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RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA (CROSBI ID 680895)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija

Banovac, Ivan ; Sedmak, Dora ; Rojnić Kuzman, Martina ; Hladnik, Ana ; Petanjek, Zdravko RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA // 7th Croatian Neuroscience Congress - Book of Abstracts. 2019. str. 34-34

Podaci o odgovornosti

Banovac, Ivan ; Sedmak, Dora ; Rojnić Kuzman, Martina ; Hladnik, Ana ; Petanjek, Zdravko

engleski

RAPID GOLGI IMPREGNATION OF PYRAMIDAL NEURONS IN THE PREFRONTAL CORTEX IN SCHIZOPHRENIA

Abnormalities in oligodendrocytes lead to altered myelination in schizophrenia, according to most recent studies. The degree of myelination affects axon impregnation in Golgi staining. Therefore, the aim of this study is to compare the axon impregnation on rapid Golgi between schizophrenic and control subjects. We analyzed sections of the prefrontal cortex containing Brodmann area 9 in five schizophrenic and five control subjects. The sections were stained using the rapid Golgi method and the axons of randomly selected pyramidal neurons of layer III and V were reconstructed using Neurolucida 4 software. The axon impregnation lengths were then compared between the schizophrenic and control groups. Our results showed an increase in the length of axonal staining of the pyramidal neurons in the prefrontal cortices of schizophrenic subjects. The length of the stained axon main trunk was 132.5 ± 63.5 µm in the schizophrenic group and 64.8 ± 20.2 µm in the control group. The difference was shown to be statistically significant (p-value on Student’s t-test was <0.05). Our analysis also revealed that more axon collaterals per neuron were stained in the schizophrenic group (14.5% on average) than in the control group (5.1% on average). The increased axonal staining in schizophrenic subjects could be explained by reduced myelination of the axons, which allows for better impregnation on Golgi staining. Such a decrease in axon myelination is in line with the neurodevelopmental model of schizophrenia, which proposes that pathology in schizophrenia is more dependent on secondary effects, rather than on a primary lesion. In conclusion, our results support that the cortical circuitry disorganization in schizophrenia is caused by oligodendrocyte abnormalities which lead to a decrease in axon myelination.

rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation

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Podaci o prilogu

34-34.

2019.

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objavljeno

Podaci o matičnoj publikaciji

7th Croatian Neuroscience Congress - Book of Abstracts

Podaci o skupu

7th Croatian Neuroscience Congress

poster

12.10.2019-15.10.2019

Zadar, Hrvatska

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti

Poveznice