engleski

First evidence of KPC-producing ST258 Klebsiella pneumoniae in river water

This paper reports the first case of Klebsiella pneumoniae carbapenemase (KPC)-2- producing K. pneumoniae in river water in Croatia. In total, four KPC-2-producing K. pneumoniae isolates were analysed. All isolates shared a similar genetic background, belonging to ST258. Isolates displayed uniform, multi-drug-resistant profiles susceptible to colistin. blaSHV-1, aac(3’)-II, aac(6’)-Ib and aph(3’)-Ia genes were detected in all isolates. In all isolates, the blaKPC-2 gene was localized on a single non-conjugative IncFII plasmid that varied in size (w140, w230, w225 and w220 kb). K. pneumoniae was viable in river water for up to 50 days, confirming its ability to survive and disseminate in the environment.

Klebsiella pneumoniae ; KPC-2-producing ; river water ; environment ; ST258 ; IncFII

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