The variability of detoxifying GSTP1 gene polymorphisms in the Roma population from Croatia (CROSBI ID 681997)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Zajc Petranović, Matea ; Špinderk, Sanja ; Stojanović Marković, Anita ; Tomas, Željka ; Škarić-Jurić, Tatjana ; Peričić Salihović, Marijana
engleski
The variability of detoxifying GSTP1 gene polymorphisms in the Roma population from Croatia
The genetic variability of xenobiotic- metabolizing enzymes contributes to individual susceptibility to environmental risk factors (outdoor pollutants, cigarette smoke, diet- related xenobiotics). Glutathione S- transferases (GSTs) are ubiquitous family of multifunctional enzymes which decrease oxidative damage in cells by catalyzing the conjugation of many toxic compounds with glutathione. The GSTP1 is a polymorphic gene whose certain variants, by altering the gene product protein structure, have been investigated as candidate loci involved in the predisposition to pathologic conditions. This study investigated rs1695 (A313G, I105V) and rs1138272 (C341T, A114V) genotypes, alleles and haplotypes in 440 members of three socio- culturally different and geographically distant Roma (Gypsy) groups. The Baranja and the Međimurje Roma groups belong to Vlax (Bayash) Roma who speak Ljimb`d Bayash, while the Balkan Roma group speaks Romani Chib. Haplotypes were inferred using Phase ver. 2.1. Both investigated loci were in Hardy-Weinberg equilibrium in all the three Roma populations. Minor allele frequency (MAF) of rs1138272 was significantly higher in the Baranja (16.4%) and in the Balkan Roma (14.9%) than in the Međimurje Roma (8.8%) (p<0.01 and p<0.05, respectively). The MAF of the rs1695 was significantly higher in the Baranja Roma (35.9%) than in the Balkan Roma (25.0%) (p<0.01). The most prevalent haplotype in all Roma groups was I105-A114, while the second most frequent in the Baranja and the Međimurje Roma was V105-A114 and in the Balkan Roma group V105-V114 (p<0.001). The analyzed GSTP1 polymorphic loci indicate that Balkan Roma significantly differ from the Baranja and the Međimurje Roma, which is in concordance with their specific histories and distant socio-cultural characteristics.
GSTP1, ADME genes, rs1138272, rs1695, pharmacogenetics, Roma (Gypsy)
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Podaci o prilogu
26-26.
2019.
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objavljeno
Podaci o matičnoj publikaciji
Genetics & applications
Bajrović, Kasim
Sarajevo: Institute for Genetic Engineering and Biotechnology, Sarajevo, Bosnia and Herzegovina
2566-2937
Podaci o skupu
1st Congress of Geneticists in Bosnia and Herzegovina with International Participation
predavanje
02.10.2019-04.10.2019
Sarajevo, Bosna i Hercegovina