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The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus (CROSBI ID 270492)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Blaslov, Kristina ; Kruljac, Ivan ; Mirošević, Gorana ; Gaćina, Petar ; Kolonić, Slobodanka Ostojić ; Vrkljan, Milan The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus // Clinical hemorheology and microcirculation, 71 (2019), 4; 475-481. doi: 10.3233/ch-180422

Podaci o odgovornosti

Blaslov, Kristina ; Kruljac, Ivan ; Mirošević, Gorana ; Gaćina, Petar ; Kolonić, Slobodanka Ostojić ; Vrkljan, Milan

engleski

The prognostic value of red blood cell characteristics on diabetic retinopathy development and progression in type 2 diabetes mellitus

BACKGROUNDAlthough it is considered that the pathogenesis of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) is primarily due to chronic hyperglycemia resulting in vascular changes and retinal ischemia, the red blood cells (RBCs) disorders might also represent an important pathophysiological risk factor.OBJECTIVETo evaluate whether the RBC properties contribute to DR development and progression in T2DM.METHODSThis prospective observational study comprised 247 persons with T2DM free of DR or with non proliferative DR without any signs of anaemia. The patients were reacessed after 60-months.RESULTSThe mean age of our study population was 56 years, 54.9% males with diabetes duration of 11, 18±1, 28 years. During the follow up, 16 (5.84%) participants developed non proliferative DR and 9 (3.64%) progressed to PDR while the mean corpuscular volume (MCV) and red cell distribution width (RDW) MCV rose. Both MCV and RDW correlated positively with HbA1c (r = 0, 468, p = 0.003 and r = 0.521, p < 0.001), while Cox regression analysis revealed that besides age, diabetes duration, HbA1c, hypertension and dyslipidemia presence, MCV and RDW are also associated with the risk of DR development and progression (HR 1.057 and 1.237, p < 0.001).CONCLUSIONSWe clearly demonstrated that RBC's characteristics might represent a risk factor for DR development and progression.

diabetic retinopathy ; mean corpuscular volume ; red blood cells ; red cell volume distribution width

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Podaci o izdanju

71 (4)

2019.

475-481

objavljeno

1386-0291

1875-8622

10.3233/ch-180422

Povezanost rada

Kliničke medicinske znanosti

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